Preliminary computational modeling of nitric oxide synthase 3 interactions with caveolin-1: influence of exon 7 Glu298Asp polymorphism
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چکیده
منابع مشابه
Prevalence of endothelial nitric oxide synthase (eNOS) gene exon 7 Glu298Asp variant in North Eastern India
BACKGROUND & OBJECTIVES Endothelial nitric oxide is a potent vasodilator and impairment of its generation brought about by gene polymorphism is considered a major predictor for several diseases. A single nucleotide polymorphism G894T within exon 7 of endothelial nitric oxide synthase (eNOS-7) gene, resulting in a replacement of glutamic acid by aspartic acid, has been studied as a putative cand...
متن کاملOutcome in prostate cancer: association with endothelial nitric oxide synthase Glu-Asp298 polymorphism at exon 7.
PURPOSE The endothelial cell-specific form of nitric oxide synthases (ecNOS) was mapped at 7q35-q36 and plays an important role in vascular development and tumor growth in human prostate cancer. Bone metastasis, clinical T-stage, tumor grade, and serum prostate-specific antigen (PSA) have been shown to have prognostic importance in the outcome of prostate cancer. The purpose of this study was t...
متن کاملEndothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis.
BACKGROUND Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to end...
متن کاملThe Study of Nitric Oxide Synthase 3 (NOS3) T-786C and 4a4b Gene Polymorphism in Iranian Men with Varicocele
Background and Objectives: Varicocele is one of the most common causes of male infertility. Varicocele is an abnormal dilatation and tortuosity of veins of the pampiniform plexus, which drain the testis. Studies have shown that elevated level of oxidative stress markers, such as nitric oxide (NO) in the dilated veins of patients with varicocele impair testicular function. The aim of this study,...
متن کاملEndothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma.
BACKGROUND AND PURPOSE The role of endothelial nitric oxide synthase (eNOS) in normal physiology suggests that it could be a potential candidate gene for stroke. Reduced eNOS activity could mediate an increased stroke risk through hypertension or independent of hypertension through abnormal vasomotor responses, promoting atherogenesis, or increased platelet adhesion and aggregation. Recently, a...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2008
ISSN: 1672-9145,1745-7270
DOI: 10.1111/j.1745-7270.2008.00369.x